Pipeline
Multiple disease areas uniquely unlocked by activating antibodies
Our specific, activating antibodies address the liabilities of other drugs for challenging targets: they have the specificity that small molecules and peptides often don’t, and the activity that other antibodies typically lack. Antibodies also have long half-lives, unlike some small molecules and peptides, improving patient compliance and making them effective for chronic conditions.
Specifically activate targets and target subpopulations to increase efficacy and reduce intolerable side effects
Activate hypertrophy to combat muscle loss during weight loss.
Activate hypertrophy to combat muscle loss during weight loss.
Metabolic
Inflammation
Activate wound-healing to address disease causes, not just treat symptoms
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Pain
Specifically and peripherally activate pain targets to avoid CNS side effects like addiction and respiratory depression , safely and effectively reducing pain.
Specifically activate targets and target subpopulations to increase efficacy and reduce intolerable side effects
Activate hypertrophy to combat muscle loss during weight loss.
Activate hypertrophy to combat muscle loss during weight loss.
Metabolic
Inflammation
Activate wound-healing to address disease causes, not just treat symptoms
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Cancer
Locally recruit and activate tumor-killing T cells to tumors with chemokine receptor activators
Activate receptor internalization to expand the therapeutic windows of ADCs.
Activate receptor internalization to expand the therapeutic windows of ADCs.
Pipeline
We have performed multiple discovery campaigns for partners and internal pipeline programs
