Pipeline
Multiple disease areas uniquely unlocked by activating antibodies
Our specific, activating antibodies address the liabilities of other drugs for challenging targets: they have the specificity that small molecules and peptides often don’t, and the activity that other antibodies typically lack. Antibodies have long half-lives, unlike some small molecules and peptides, making them very effective for chronic conditions. Antibodies also have the chemical and large structural complexity to better mimic large ligands, like chemokines, and interact with multiple parts of the target for effective activation.
Specifically activate targets and target subpopulations to increase efficacy and reduce intolerable side effects
Activate hypertrophy to combat muscle loss during weight loss.
Activate hypertrophy to combat muscle loss during weight loss.
Metabolic
Inflammation
Activate wound-healing to address disease causes, not just treat symptoms
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Cancer
Locally recruit and activate tumor-killing T cells to tumors with chemokine receptor activators
Activate receptor internalization to expand the therapeutic windows of ADCs.
Activate receptor internalization to expand the therapeutic windows of ADCs.
Specifically activate targets and target subpopulations to increase efficacy and reduce intolerable side effects
Activate hypertrophy to combat muscle loss during weight loss.
Activate hypertrophy to combat muscle loss during weight loss.
Metabolic
Inflammation
Activate wound-healing to address disease causes, not just treat symptoms
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Allosterically activate hydrophobic ligand responsive receptors from the outside of the cell, sidestepping problems of hydrophobic drugs that bind orthosterically.
Cancer
Locally recruit and activate tumor-killing T cells to tumors with chemokine receptor activators
Activate receptor internalization to expand the therapeutic windows of ADCs.
Activate receptor internalization to expand the therapeutic windows of ADCs.
Pipeline
We have performed multiple discovery campaigns for partners and internal pipeline programs
