Massively parallel search by burning the haystack
The foundation of Abalone Bio’s Functional Antibody Selection Technology (FAST) platform is a highly engineered yeast cell chassis.
Using the latest tools in synthetic biology, we incorporate human targets into our FAST platform cells. We then genetically encode a different antibody variant in every cell. Cells make and test the antibody they carry. Cells with a Bioactive Antibody grow, while others don't.
We monitor the function of thousands of antibodies at once
Using next-generation sequencing, we measure millions of examples of how antibody sequences relate to their ability to control GPCR function. These proprietary sequence-function datasets power insight into antibody-GPCR structure-function relationships for better hit selection.
Every selection improves the next
With insights from each experiment transferrable to the next, our platform grows more powerful with every selection campaign, a positive feedback loop that grows our competitive advantage over time.