Measure, find, learn, design

Combining synthetic biology and AI to measure, find, learn about, and finally design rare antibody modulators of promising undrugged targets

Live to function, function to live

Massively parallel search by burning the haystack

The foundation of Abalone Bio’s Functional Antibody Selection Technology (FAST) platform is a highly engineered yeast cell chassis.

Using the latest tools in synthetic biology, we incorporate human targets into our FAST platform. We then genetically encode a different antibody variant in every cell. Each cell makes and tests one antibody variant for function, not just binding.

Key differentiators

  • Yeast cells are a "clean breadboard", unlike mammalian cells with hundreds of GPCRs present, eliminating cross-talk
  • Using biology means fast, massively parallel, high-throughput search. Test hundreds of millions of antibody variants at once, 100X+ more than other methods.

Proprietary functional dat powers AI design of novel modulating antibodies.

Functional data at unprecedented library scale to finally power AI to find better hits, faster

We measure the function of hundreds of millions of antibody in parallel, an unprecedented scale. These datasets power our bioinformatic and ML engine to learn antibody sequence-function relationships and develop better hits faster.

Every selection improves the next

With ML-powered insights from each experiment transferrable to the next, our platform grows more powerful with every selection campaign, a positive feedback loop that grows our competitive advantage over time.