Harnessing Nature's
search function:
Survival of the fittest
Combining synthetic biology and computation to find active antibodies for GPCRs
Massively parallel search by burning the haystack
The foundation of Abalone Bio’s Functional Antibody Selection Technology (FAST) platform is a highly engineered yeast cell chassis.
Using the latest tools in synthetic biology, we incorporate human targets into our FAST platform cells. We then genetically encode a different antibody variant in every cell. Cells make and test the antibody they carry. Cells with a Bioactive Antibody grow, while others don't.
Advantages include:
We monitor the function of thousands of antibodies at once
Using next-generation sequencing, we measure millions of examples of how antibody sequences relate to their ability to control GPCR function. These proprietary sequence-function datasets power insight into antibody-GPCR structure-function relationships for better hit selection.
Every selection improves the next
With insights from each experiment transferrable to the next, our platform grows more powerful with every selection campaign, a positive feedback loop that grows our competitive advantage over time.
